PULSATILE DRUG DELIVERY: A STRATEGY FOR TREATING CHRONOTHERAPEUTIC AILMENTS

Modern drug delivery systems have been promoted to a unique notion of chronopharmacology, i.e., the ability provide medicament patient in staggered profile, as discipline chronobiology has advanced. The main disadvantage developing such system that fits circadian cycle is lack accurate technology (Pulsatile system, PDDS). Pulsatile devices are gaining popularity because they deliver medicine correct region action at time, allowing for spatial and temporal dosing compliance among patients. These technologies meant work with body's natural cycle. rhythm affects various biological humans, including metabolism, physiology, behaviour, sleep patterns, hormone synthesis, so on. This article addresses several methods, osmotic systems, capsular single multiple-unit programable rely on soluble or erodible polymer coatings, usage rupturable membranes. present review covered rationale creation pulsatile benefits, limitations types diseases require release, categorization, assessments delivery.